DESCRIPTION

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

General description

Amyloid β Protein Fragment 1-40 (Aβ40) is derived from the amyloid-β protein (Aβ), which is mapped to human chromosome 21q21.3. Aβ40 is predominantly current within the vascular amyloid deposits. Aβ40 includes of C-terminal membrane insertion area. It reveals structural transition from random coil to a α-helical construction in a water-micelle medium.

Application

Amyloid β Protein Fragment 1-40 has been used:

  • within the temperature based mostly conformational research utilizing Fourier remodel infrared/differential scanning calorimetry (FT-IR/DSC) research
  • as a reference normal in sandwich-type enzyme immunoassay for quantifying amyloid A4 protein in cerebrospinal fluid of sufferers with head trauma
  • as a part of embryonic stem cell medium to inhibit amyloid deposition in fibroblasts

Biochem/physiol Actions

Amyloid β-protein is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. β-Amyloid peptides (amino acids 1-42 and 1-43) are the foremost constituents of senile plaques and neurofibrillary tangles that happen within the hippocampus, neocortex, and amygdala of sufferers with Alzheimer′s illness.
Amyloid β Protein Fragment 1-40 (Aβ40) kinds cation based mostly ion channels.

Reconstitution

For maximal organic exercise, dilute the inventory in calcium-free PBS to 1 mg/ml and incubate at 37 °C for four days.

Other Notes

Lyophilized from 0.1% TFA in H2O
amyloid

amyloid

Abstract

Alzheimer’s illness (AD) pathogenesis is broadly believed to be pushed by the manufacturing and deposition of the β-amyloid peptide (Aβ). For a few years, investigators have been puzzled by the weak to nonexistent correlation between the quantity of neuritic plaque pathology within the human mind and the diploma of scientific dementia. Recent advances in our understanding of the event of amyloid pathology have helped remedy this thriller. Substantial proof now signifies that the solubility of Aβ, and the amount of Aβ in numerous swimming pools, could also be extra carefully associated to illness state. The composition of those swimming pools of Aβ displays completely different populations of amyloid deposits, and has particular correlates with the scientific standing of the affected person. Imaging applied sciences, together with new amyloid imaging brokers based mostly on the chemical construction of histologic dyes, at the moment are making it potential to trace amyloid pathology together with illness development within the dwelling affected person. Interestingly, these approaches point out that the Aβ deposited in AD is completely different from that present in animal fashions. In basic, deposited Aβ is extra simply cleared from the mind in animal fashions, and doesn’t present the identical bodily and biochemical traits because the amyloid present in AD. This raises essential points relating to the event and testing of future therapeutic brokers.

Keywords: Amyloid, β-Amyloid Precursor Protein, Aβ, oligomer, fibril
Beta Amyloid
MO22142 100 ul
EUR 435
beta Amyloid 40 protein
30R-3013 500 ug
EUR 327
Description: Purified recombinant beta Amyloid 40 protein
beta Amyloid 42 protein
30R-3014 500 ug
EUR 327
Description: Purified recombinant beta Amyloid 42 protein
Beta Amyloid antibody
70R-51450 100 ul
EUR 287
Description: Purified Polyclonal Beta Amyloid antibody
beta Amyloid antibody
70R-AR020 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody
beta Amyloid antibody
70R-BR019 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody
beta Amyloid Antibody
35506-100ul 100ul
EUR 390
beta Amyloid antibody
10R-7917 100 ug
EUR 322
Description: Mouse monoclonal beta Amyloid antibody
beta Amyloid antibody
10R-A124a 50 ug
EUR 1011
Description: Mouse monoclonal beta Amyloid antibody
beta Amyloid antibody
20R-AR011 250 ul
EUR 381
Description: Rabbit polyclonal beta Amyloid antibody
beta-Amyloid antibody
22965-100ul 100ul
EUR 390
beta Amyloid antibody
70R-12571 100 ul
EUR 457
Description: Affinity purified Rabbit polyclonal beta Amyloid antibody
beta Amyloid antibody
70R-10624 1 ml
EUR 693
Description: Affinity purified Chicken polyclonal beta Amyloid antibody
Amyloid beta 1-42 Protein
abx060277-100ug 100 ug
EUR 759
  • Shipped within 5-10 working days.
Amyloid beta (A4) Precursor Protein
20-abx260881
  • EUR 3418.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.
Amyloid beta Protein (20-29)
20-abx266170
  • EUR 439.00
  • EUR 718.00
  • EUR 328.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.
Amyloid beta Protein (33-42)
20-abx266417
  • EUR 537.00
  • EUR 899.00
  • EUR 384.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.
Amyloid beta-Protein (1-43)
5-00662 4 x 1mg Ask for price
Amyloid beta-Protein (20-29)
5-00663 4 x 5mg Ask for price
Amyloid beta-Protein (29-40)
5-00665 4 x 1mg Ask for price
Amyloid beta-Protein (33-42)
5-00666 4 x 5mg Ask for price
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