Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells.

Bacterial pathogens have developed particular effector proteins that, by interfacing with host kinase signalling pathways, present a mechanism to evade immune responses throughout an infection. Although these effectors contribute to pathogen virulence, we realized that they may additionally serve as worthwhile artificial biology reagents for engineering mobile behaviour. Here we exploit two effector proteins, the Shigella flexneri … Read more