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It is believed that prenatal vitamin D deficiency can contribute to the development of wheezing and childhood asthma. In addition to its well-known functions for bone development and health, vitamin D occurs as a pleiotropic hormone that exerts several extrasceletal effects, some of which could reduce the risk of asthma. Experimental evidence shows that vitamin D is an important regulator of fetal and neonatal lung growth. It can also modulate innate and adaptive immune responses, improve antiviral and antimicrobial defense on epithelial surfaces, and inhibit some inflammatory responses associated with asthma and allergic diseases.
