In our earlier research, utilizing a B cell vaccine (scFv-Her2), the concentrating on of tumor-associated antigen Her2 (human epidermal progress issue receptor-2) to B cells by way of the anti-CD19 single chain variable fragment (scFv) was proven to enhance tumor-specific immunity, which enhanced tumor management in the prophylactic and therapeutic setting. However, the fusion protein displayed restricted exercise in opposition to established tumors, and native relapses usually occurred following scFv-Her2 remedy, indicating that scFv-Her2-induced responses are insufficient to take care of anti-tumor immunity.
In this research, concentrating on the IV area (D4) of the extracellular area of Her2 to B cells by way of CD19 molecules (scFv-Her2D4) was discovered to reinforce IFN-γ-producing-CD8+ T cell infiltration in tumor tissues and decreased the variety of tumor-infiltrating myeloid-derived suppressor cells (MDSCs). However, adverse co-stimulatory molecules comparable to programmed cell loss of life protein-1 (PD-1), CD160, and LAG-Three on T cells and programmed loss of life protein ligand-1 (PD-L1) on tumor cells have been upregulated in the tumor microenvironment after scFv-Her2D4 remedy. Further, anti-PD1 administration enhanced the efficacy of scFv-Her2D4 and anti-tumor immunity, as evidenced by the reversal of tumor-infiltrating CD8+ T cell exhaustion and the discount of MDSCs and Treg cells, which suppress T cells and alter the tumor immune microenvironment.
Moreover, combining this with anti-PD1 antibodies promoted full tumor rejection. Our knowledge present proof of an in depth interplay amongst tumor vaccines, T cells, and the PD-L1/PD-1 axis and set up a foundation for the rational design of mixture remedy with immune modulators and tumor vaccine remedy.
CD19-targeting fusion protein combined with PD1 antibody enhances anti-tumor immunity in mouse models.
Anti-inflammatory, analgesic exercise, and toxicity of Pituranthos scoparius stem extract: An ethnopharmacological research in rat and mouse fashions.
<AbstractText>Pituranthos scoparius is a medicinal plant that’s used in conventional drugs in Algeria and different North African nations to deal with a number of illnesses comparable to bronchial asthma, rheumatism, measles, dermatoses, jaundice, and digestive problems.</AbstractText><AbstractText>The current investigation was designed to research an ethnobotanical survey about Pituranthos scoparius in Setif area, Algeria, and assess the acute toxicity, in vivo anti-inflammatory potential and analgesic impact of Pituranthos scoparius stem h widespread drugs.</AbstractText><p><div><b>MATERIALS AND METHODS</b></div>Acute toxicity of PSSE was carried out primarily based on OECD pointers 425.
Both potential loss of life and indicators accompanying toxicity of animals have been monitored for 14 days to determine the median deadly dose (LD<sub>50</sub>) of PSSE. Anti-inflammatory impact of the extract was evaluated utilizing the xylene, croton oil-induced ear edema, and carrageenan-induced paw edema, whereas the analgesic exercise was evaluated utilizing acetic acid-induced stomach constriction in mice mannequin.</p><p><div><b>RESULTS</b></div>Data from the ethnopharmacological survey confirmed that 24.47% of individuals used this plant in conventional (people) drugs Results additionally revealed that PSSE comprises excessive quantities of polyphenols, flavonoids, and tannins, and that the extract didn’t trigger any deaths or adjustments in the conduct of handled animals; LD<sub>50</sub> values have been discovered to be greater than 5 g/kg DW.
 Mouse Monoclonal Anti-Human CD19 FITC/CD5 PE |
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| CD19-D3-50 | Alpha Diagnostics | 50 tests | EUR 651 |
 ELISA Kit) Human Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RD-CD19-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 500 |
Human Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RD-CD19-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 692 |
 ELISA Kit) Mouse Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RD-CD19-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 511 |
Mouse Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RD-CD19-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 709 |
 ELISA Kit) Rat Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RD-CD19-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 534 |
Rat Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RD-CD19-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 742 |
Human Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RDR-CD19-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 522 |
Human Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RDR-CD19-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 724 |
Mouse Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RDR-CD19-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 534 |
Mouse Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RDR-CD19-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 742 |
Rat Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RDR-CD19-Ra-48Tests | Reddot Biotech | 48 Tests | EUR 558 |
Rat Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| RDR-CD19-Ra-96Tests | Reddot Biotech | 96 Tests | EUR 776 |
Human Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| DLR-CD19-Hu-48T | DL Develop | 48T | EUR 498 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Cluster Of Differentiation 19 (CD19) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Human Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| DLR-CD19-Hu-96T | DL Develop | 96T | EUR 647 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Cluster Of Differentiation 19 (CD19) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Mouse Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| DLR-CD19-Mu-48T | DL Develop | 48T | EUR 508 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cluster Of Differentiation 19 (CD19) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Mouse Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| DLR-CD19-Mu-96T | DL Develop | 96T | EUR 661 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Cluster Of Differentiation 19 (CD19) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Rat Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| DLR-CD19-Ra-48T | DL Develop | 48T | EUR 528 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation 19 (CD19) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Rat Cluster Of Differentiation 19 (CD19) ELISA Kit |
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| DLR-CD19-Ra-96T | DL Develop | 96T | EUR 690 |
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Description: A sandwich quantitative ELISA assay kit for detection of Rat Cluster Of Differentiation 19 (CD19) in samples from tissue homogenates, cell lysates or other biological fluids. |
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 CD19 |
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| 19A1-100T | ImmunoStep | 100 test | EUR 349 |
CD19 |
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| 19AC750-100T | ImmunoStep | 100 test | EUR 570 |
CD19 |
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| 19B1-01MG | ImmunoStep | 100 test | EUR 284 |
CD19 |
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| 19CFB1-100T | ImmunoStep | 100 test | EUR 388 |
CD19 |
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| 19F1-100T | ImmunoStep | 100 test | EUR 297 |
CD19 |
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| 19PC54-100T | ImmunoStep | 100 test | EUR 724.7 |
CD19 |
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| 19PC74-100T | ImmunoStep | 100 test | EUR 388 |
CD19 |
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| 19PE1-100T | ImmunoStep | 100 test | EUR 349 |
CD19 |
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| 19PP1-100T | ImmunoStep | 100 test | EUR 349 |
CD19 |
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| 19PPC5.51-100T | ImmunoStep | 100 test | EUR 466 |
CD19 |
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| 19PU1-01MG | ImmunoStep | 0,1 mg | EUR 219 |
CD19 |
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| MO19A(V100) | ImmunoStep | 100 ug | EUR 50 |
CD19 |
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| MO19A(V25) | ImmunoStep | 25 ug | EUR 50 |
CD19 |
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| MO19B(V100) | ImmunoStep | 100 ug | EUR 50 |
CD19 |
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| MO19B(V25) | ImmunoStep | 25 ug | EUR 50 |
CD19 |
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| MO19CFB(V100) | ImmunoStep | 100 ug | EUR 50 |
CD19 |
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| MO19CFB(V25) | ImmunoStep | 25 ug | EUR 50 |
CD19 |
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| MO19F(V100) | ImmunoStep | 100 ug | EUR 50 |
CD19 |
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| MO19F(V25) | ImmunoStep | 25 ug | EUR 50 |
CD19 |
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| MO19F(V500) | ImmunoStep | 500 ug | EUR 50 |
CD19 |
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| MO19PE(V100) | ImmunoStep | 100 ug | EUR 50 |
CD19 |
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| MO19PE(V25) | ImmunoStep | 25 ug | EUR 50 |
CD19 |
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| MO19PP(V100) | ImmunoStep | 100 ug | EUR 50 |
CD19 |
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| MO19PP(V25) | ImmunoStep | 25 ug | EUR 50 |
CD19 |
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| MO19PP5.5(V100) | ImmunoStep | 100 ug | EUR 50 |
CD19 |
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| MO19PP5.5(V25) | ImmunoStep | 25 ug | EUR 50 |
CD19 |
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| MO19PU(V100) | ImmunoStep | 100 ug | EUR 50 |
CD19 |
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| MO19PU(V500) | ImmunoStep | 500 ug | EUR 50 |
CD19 |
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| PR27300 | Neuromics | 5 ug | EUR 318 |
) Human B-lymphocyte antigen CD19 (CD19) |
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| 1-CSB-CF004888HU | Cusabio |
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Description: Recombinant Human B-lymphocyte antigen CD19(CD19),partial expressed in in vitro E.coli expression system |
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Human B-lymphocyte antigen CD19 (CD19) |
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| 1-CSB-CF004888HUc7 | Cusabio |
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Description: Recombinant Human B-lymphocyte antigen CD19(CD19),partial expressed in in vitro E.coli expression system |
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 Antibody) B-Lymphocyte Antigen CD19 (CD19) Antibody |
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| abx159376-100ul | Abbexa | 100 ul | EUR 356 |
B-Lymphocyte Antigen CD19 (CD19) Antibody |
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| abx159377-100ul | Abbexa | 100 ul | EUR 356 |
B-Lymphocyte Antigen CD19 (CD19) Antibody |
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| abx159378-100ul | Abbexa | 100 ul | EUR 356 |
B-Lymphocyte Antigen CD19 (CD19) Antibody |
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| abx159379-100ul | Abbexa | 100 ul | EUR 356 |
B-Lymphocyte Antigen CD19 (CD19) Antibody |
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| abx159380-100ul | Abbexa | 100 ul | EUR 439 |
B-Lymphocyte Antigen CD19 (CD19) Antibody |
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| abx159381-100ul | Abbexa | 100 ul | EUR 356 |
B-Lymphocyte Antigen CD19 (CD19) Antibody |
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| abx011636-100ul | Abbexa | 100 ul | EUR 411 |
 CD19 antibody |
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| 70R-49501 | Fitzgerald | 100 ul | EUR 287 |
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Description: Purified Polyclonal CD19 antibody |
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 CD19 Antibody |
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| AF6181 | Affbiotech | 200ul | EUR 304 |
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Description: CD19 Antibody detects endogenous levels of total CD19. |
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CD19 Antibody |
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| BF0411 | Affbiotech | 200ul | EUR 376 |
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Description: CD19 antibody detects endogenous levels of total CD19. |
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CD19 Antibody |
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| ABF6181 | Lifescience Market | 100 ug | EUR 438 |
CD19 Antibody |
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| ABD7030 | Lifescience Market | 100 ug | EUR 438 |
 anti-CD19 |
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| YF-PA10772 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to CD19 |
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anti-CD19 |
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| YF-PA23389 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to CD19 |
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 pCMV6- CD19 |
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| PVT10226 | Lifescience Market | 2 ug | EUR 301 |
CD19 antibody |
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| 70R-30866 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal CD19 antibody |
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CD19 Antibody |
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| 32727-100ul | SAB | 100ul | EUR 252 |
CD19 antibody |
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| 10R-1794 | Fitzgerald | 100 ul | EUR 241 |
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Description: Mouse monoclonal CD19 antibody |
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CD19 antibody |
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| 10R-1895 | Fitzgerald | 100 ul | EUR 381 |
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Description: Mouse monoclonal CD19 antibody |
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CD19 antibody |
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| 10R-3608 | Fitzgerald | 100 ul | EUR 691 |
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Description: Mouse monoclonal CD19 antibody |
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CD19 antibody |
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| 10R-CD19aMS | Fitzgerald | 500 ug | EUR 413 |
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Description: Rat monoclonal CD19 antibody |
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CD19 antibody |
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| 10R-CD19bHU | Fitzgerald | 100 ug | EUR 262 |
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Description: Mouse monoclonal CD19 antibody |
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CD19 antibody |
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| 10R-CD19cHU | Fitzgerald | 100 ug | EUR 241 |
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Description: Mouse monoclonal CD19 antibody |
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CD19 antibody |
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| 10R-CD19dMS | Fitzgerald | 500 ug | EUR 403 |
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Description: Mouse monoclonal CD19 antibody |
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CD19 antibody |
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| 10R-6362 | Fitzgerald | 100 ug | EUR 170 |
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Description: Rat monoclonal CD19 antibody |
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CD19 Antibody |
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| 49388-100ul | SAB | 100ul | EUR 333 |
CD19 Antibody |
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| 49388-50ul | SAB | 50ul | EUR 239 |
CD19 Antibody |
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| 49407-100ul | SAB | 100ul | EUR 333 |
CD19 Antibody |
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| 49407-50ul | SAB | 50ul | EUR 239 |
 CD5/CD19 |
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| 5F19PE1-50T | ImmunoStep | 50 test | EUR 350.3 |
 CD3/CD19 |
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| 3F119PE1-50T | ImmunoStep | 50 test | EUR 350.3 |
CD19 Antibody |
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| DF7030 | Affbiotech | 200ul | EUR 304 |
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Description: CD19 Antibody detects endogenous levels of total CD19. |
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 LAMBDA/CD19 |
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| LAMBDAF19PE1-50T | ImmunoStep | 50 test | EUR 350.3 |
LAMBDA/CD19 |
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| LF219PE4-50T | ImmunoStep | 50 test | EUR 466 |
CD19 antibody |
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| PAab09868 | Lifescience Market | 100 ug | EUR 386 |
CD19 Antibody |
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| 1-CSB-PA001431 | Cusabio |
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Description: A polyclonal antibody against CD19. Recognizes CD19 from Human, Mouse, Monkey. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000 |
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CD19 Antibody |
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| 1-CSB-PA006159 | Cusabio |
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Description: A polyclonal antibody against CD19. Recognizes CD19 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/10000 |
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 KAPPA/CD19 |
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| KF319PE4-50T | ImmunoStep | 50 test | EUR 466 |
KAPPA/CD19 |
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| KAPPAF219PE1-50T | ImmunoStep | 50 test | EUR 350.3 |
 CD19 siRNA |
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| 20-abx910940 | Abbexa |
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CD19 siRNA |
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| 20-abx910941 | Abbexa |
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) Recombinant Cynomolgus CD19/CD19 Molecule (C-Fc) |
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| CW08-10ug | Novoprotein | 10ug | EUR 202 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Cynomolgus CD19/CD19 Molecule (C-Fc) |
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| CW08-1mg | Novoprotein | 1mg | EUR 3298 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Cynomolgus CD19/CD19 Molecule (C-Fc) |
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| CW08-500ug | Novoprotein | 500ug | EUR 2323 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Cynomolgus CD19/CD19 Molecule (C-Fc) |
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| CW08-50ug | Novoprotein | 50ug | EUR 496 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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 Human B- lymphocyte antigen CD19, CD19 ELISA KIT |
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| ELI-06013h | Lifescience Market | 96 Tests | EUR 824 |
 Mouse B- lymphocyte antigen CD19, Cd19 ELISA KIT |
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| ELI-06014m | Lifescience Market | 96 Tests | EUR 865 |
 ELISA Kit) Mouse B-Lymphocyte Antigen CD19 (CD19) ELISA Kit |
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| abx570286-96tests | Abbexa | 96 tests | EUR 668 |
 ELISA Kit) Human B-Lymphocyte Antigen CD19 (CD19) ELISA Kit |
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| abx572501-96tests | Abbexa | 96 tests | EUR 668 |
Human B-Lymphocyte Antigen CD19 (CD19) ELISA Kit |
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| abx352417-96tests | Abbexa | 96 tests | EUR 668 |
Mouse B-Lymphocyte Antigen CD19 (CD19) ELISA Kit |
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| abx255037-96tests | Abbexa | 96 tests | EUR 668 |
 ELISA Kit) Rat B-Lymphocyte Antigen CD19 (CD19) ELISA Kit |
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| 20-abx155323 | Abbexa |
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Mouse B-Lymphocyte Antigen CD19 (CD19) ELISA Kit |
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| 20-abx153798 | Abbexa |
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Human B-Lymphocyte Antigen CD19 (CD19) ELISA Kit |
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| 20-abx150992 | Abbexa |
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 Human CD19/ B-lymphocyte antigen CD19 ELISA Kit |
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| E2752Hu | Sunlong | 1 Kit | EUR 571 |
 Mouse Cd19/ B-lymphocyte antigen CD19 ELISA Kit |
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| E0242Mo | Sunlong | 1 Kit | EUR 571 |
 CD19 Conjugated Antibody |
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| C49388 | SAB | 100ul | EUR 397 |
 CD19 Blocking Peptide |
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| AF6181-BP | Affbiotech | 1mg | EUR 195 |
CD19 Blocking Peptide |
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| BF0411-BP | Affbiotech | 1mg | EUR 195 |
 anti- CD19 antibody |
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| FNab09868 | FN Test | 100µg | EUR 548.75 |
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Description: Antibody raised against CD19 |
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) Anti-CD19 (1G3) |
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| YF-MA12316 | Abfrontier | 50 ug | EUR 363 |
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Description: Mouse monoclonal to CD19 |
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Anti-CD19 (1G3) |
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| YF-MA12317 | Abfrontier | 200 ul | EUR 363 |
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Description: Mouse monoclonal to CD19 |
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) Anti-CD19 (1C9) |
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| YF-MA12318 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to CD19 |
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) CD19 antibody (Tyr531) |
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| 70R-30865 | Fitzgerald | 100 ug | EUR 327 |
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Description: Rabbit polyclonal CD19 antibody (Tyr531) |
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) CD19 antibody (FITC) |
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| 61R-1060 | Fitzgerald | 100 ug | EUR 300 |
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Description: Mouse monoclonal CD19 antibody (FITC) |
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CD19 antibody (FITC) |
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| 61R-1061 | Fitzgerald | 100 ug | EUR 300 |
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Description: Rat monoclonal CD19 antibody (FITC) |
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) CD19 antibody (PE) |
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| 61R-1218 | Fitzgerald | 100 ug | EUR 316 |
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Description: Mouse monoclonal CD19 antibody (PE) |
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CD19 antibody (PE) |
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| 61R-1219 | Fitzgerald | 100 ug | EUR 316 |
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Description: Rat monoclonal CD19 antibody (PE) |
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) CD19 antibody (biotin) |
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| 61R-1478 | Fitzgerald | 100 ug | EUR 284 |
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Description: Mouse monoclonal CD19 antibody (biotin) |
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CD19 antibody (biotin) |
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| 61R-1479 | Fitzgerald | 100 ug | EUR 284 |
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Description: Rat monoclonal CD19 antibody (biotin) |
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Additionally, no important variations have been noticed in the alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) enzymes, or in the degrees of urea and creatinine. Oral administration of PSSE on the doses of 100, 300, and 600 mg/kg produced a big dose-dependent inhibition impact in each xylene and croton oil-induced ear edema in mice. Administration of PSSE at a dose of 100, 250, and 500 mg/kg considerably (P ˂ 0.05) exhibited anti-edematogenic impact in the carrageenan-induced rat paw edema after Three h.